Which DNA Health Test Should You Get?
Full genome tests are very different from standard ancestry kits. This guide explains each option in plain English — what you actually get, who it's right for, and what the catches are.
Short Answer
SelfDecode (from $318) is best if you want AI-generated health plans — diet, supplement, and lifestyle recommendations built from your DNA. Dante Labs (from €169 on sale) is best if you want your complete genome sequenced (100% of DNA) for rare variant detection and raw data ownership. Sequencing.com ($379) is best if you want full genome sequencing plus a modular app store to choose exactly which analyses to run. Source: official pricing and specifications as of February 2026.
Quick Answer: What Do You Want?
These three services do fundamentally different things. Pick based on your goal.
Key distinction: SelfDecode tells you what to do about your DNA (action plans). WGS providers (Dante Labs, Sequencing.com) show you what's in your DNA (raw data). Many biohackers do both — get WGS first, then upload to SelfDecode.
Price Comparison
All prices as of February 2026. See individual reviews for sale pricing.
| Test | Type | Price | Raw FASTQ Files | Rating |
|---|---|---|---|---|
| Dante Labs | 30x WGS | €399 (~$430) | Included free | 6.5 / 10 |
| Sequencing.com | 30x WGS | $379 | BAM + VCF included | 8.7 / 10 |
| SelfDecode | AI analysis | From $318 | Not available | 9.1 / 10 |
What You Actually Receive
These three services deliver fundamentally different things.
Personal Health Guide
- + 500+ health reports with action items
- + Personalized supplement protocols
- + Diet & lifestyle recommendations
- + Sleep & fitness optimization
- - No raw data files (reports only)
- - Ongoing subscription required
Your Complete Genome
- + 100% of your DNA (6.4B base pairs)
- + FASTQ + BAM + VCF raw data files
- + Rare variant & carrier detection
- + Pharmacogenomics (drug response)
- - Weak built-in reports
- - 12+ week wait, poor support
Genome + App Ecosystem
- + WGS + Array hybrid (most complete)
- + 200+ analysis apps to choose from
- + Upload existing data for free
- + BAM + VCF raw data included
- - Apps cost extra ($10-$100 each)
- - Confusing subscription tiers
Dante Labs
Best sequencing quality, worst customer service
Dante Labs uses the newest Illumina NovaSeq X sequencers — the same hardware used in hospital research labs — and they include your complete raw data files (FASTQ, BAM, and VCF) in the base price, which competitors charge extra for. The standard price is €399 (around $430 USD), with occasional flash sales around €169 during events like Black Friday or DNA Day. Free global shipping is included. The serious catch: Dante Labs has a Better Business Bureau 'F' rating. Shipping delays of 12–16 weeks are common and customer support regularly goes unanswered. Buy with a credit card that has dispute protection, and treat the wait time as 4 months, not 8 weeks.
Best for
- EU-based buyers who want the highest-quality 30x sequencing
- People who want all raw data files included — FASTQ, BAM, and VCF at no extra cost
- Patient, tech-savvy users who just want the raw data and nothing else
- Biohackers who plan to use third-party tools (Promethease, FoundMyFitness, etc.)
Not ideal if
- Anyone who needs good customer support — BBB 'F' rating is a real warning
- Buyers who need results within 10 weeks
- People who want a polished app with easy-to-read reports
- First-time buyers who may need hand-holding through the process
Sequencing.com
Best for modular, app-based analysis
Sequencing.com takes a different approach from everyone else: think of it like an 'app store' for your DNA. You buy the genome sequencing ($379), and then you can purchase individual analysis apps — one for heart health, one for fitness, one for rare diseases, and so on. This gives you enormous flexibility to dig into specific topics without paying for a bundle of reports you don't need. They also give you full raw data access (BAM and VCF files). The ongoing subscription tiers (Premium at $39/month, Professional at $129/month) unlock more apps and features. If you already have data from 23andMe or Ancestry, you can upload that instead of buying a new kit.
Best for
- Tech-savvy users who want to pick and choose specific analysis apps
- Developers or researchers who need API access to their genome data
- People who already have a 23andMe or Ancestry result and want deeper analysis
- Users who want to try different health lenses over time (add apps later)
Not ideal if
- People who want a single polished report with clear conclusions
- Budget shoppers — the app store model means costs add up
- Users who want a straightforward all-in-one experience
SelfDecode
Best if you already have a 23andMe or Ancestry result
SelfDecode is not a sequencing company — it's an AI analysis platform. You upload your existing DNA file (from 23andMe, AncestryDNA, or a VCF from any WGS provider), and their AI uses a technique called 'imputation' to fill in approximately 83 million genetic positions from your ~700,000 tested positions. Think of it as the AI making educated guesses about the variants it wasn't given, based on known patterns. The result is over 500 health reports with prioritised supplement and lifestyle recommendations. Important to know: uploading your existing DNA data costs $318, and this requires an ongoing subscription on top — either around $10/month or $99/year. So the total first-year cost for someone with an existing 23andMe file is approximately $417. Bundle packages (which include the upload and subscription together) start at $499.
Best for
- People who already have 23andMe or AncestryDNA data they want to use more deeply
- Users who want AI-generated, actionable health recommendations (not just data)
- Anyone interested in supplements, sleep, fitness, or mental health optimisation
- People who want clear, readable reports — not raw scientific output
Not ideal if
- Anyone expecting a complete genome sequence — SelfDecode analyses a subset of your variants
- Budget shoppers — the bundle pricing is significantly higher than a basic ancestry kit
- Users who want maximum raw data portability (FASTQ files not available)
Sources & Methodology
- Dante Labs official specifications: Illumina NovaSeq X, 30x coverage, ≥90% Q30. dantelabs.com
- Sequencing.com product page: 30x WGS, 200+ apps, BAM/VCF included. sequencing.com
- SelfDecode methodology: AI imputation expanding ~700K SNPs to 83M variants. selfdecode.com
- Illumina NovaSeq X specifications: Q30 ≥90%, paired-end 2×150 bp reads. illumina.com
- User reports aggregated from Reddit r/biohackers, r/genomics, and Trustpilot reviews (500+ reports analyzed, February 2026).
- McCarthy et al. (2016). "A reference panel of 64,976 haplotypes for genotype imputation." Nature Genetics, 48(10), 1279-1283. doi:10.1038/ng.3643
Looking for ancestry and family history instead?
Health genome tests are different from ancestry kits. If you're primarily interested in finding relatives and exploring your heritage, see our ancestry test guide.
Compare Ancestry DNA Tests →